Use of Aceclofenac in patients with hepatic porphyria may trigger an attack.

Caution in patients with a history of hypertension and/or heart failure as fluid retention and oedema have been reported in association with NSAID therapy.

butronic dating-75butronic dating-67

SLE and mixed connective tissue disease: In patients with systemic lupus erythematosus (SLE) and mixed connective tissue disorders there may be an increased risk of aseptic meningitis.

Female fertility: The use of Aceclofenac may impair female fertility and is riot recommended in women attempting to conceive.

In view of the known effects of NSAIDs on the foetal cardiovascular system (risk of closure of the ductus arteriosus), use in the last trimester of pregnancy Is contraindicated.

The onset of labour may be delayed and the duration increased with an Increased bleeding tendency in both mother and child.

Patients at greatest risk of this reaction are those with impaired renal function, cardiac impairment, liver dysfunction, those taking diuretics and the elderly.

Renal function should be monitored in these patients.Lithium: Aceclofenac, like many NSAIDs, may increase plasma concentrations of lithium.Cardiac Glycosides: Through their renal effects, NSAIDs may increase plasma glycoside (including digoxin) levels, exacerbate cardiac failure and reduce the glomerular filtration rate in patients receiving glycosides.Caution should be advised in patients receiving concomitant medications which could increase the risk of gastrotoxicity or bleeding, such as corticosteroids, or anticoagulants such as warfarin or anti-platelet agents such as aspirin.When GI bleeding or ulceration occurs in patients receiving Aceclofenac the treatment should be withdrawn.Diuretics: Aceclofenac, like other NSAIDs, may inhibit the activity of diuretics.